Finally, we found that patients with a moderate/severe disease presented higher levels of MG-H1 and RAGE and IL-1β expression, as well as lower levels of Glo1 expression compared with the non-severe group, thus strongly suggesting that the mechanistic in vitro core results, showing the MG-H1/RAGE pathway as a novel SARS-CoV-2 S1-driven pro-inflammatory axis, might also occur during infection. The gene discussed is GLO1; the disease is infection.