In 2021, Tiane et al. [62] targeted inhibition of the Id2 and Id4 DNA protein inhibitors by dCas9-DNMT3A and found that DNA methylation of Id2 and Id4 expression is important in the differentiation of oligodendrocyte progenitor cells, which is maladjusted in multiple sclerosis. Here, ID2 is linked to multiple sclerosis.