To investigate the interplay of Ogr1 and Tdag8 in the development of acute intestinal inflammation, 12–15-week-old WT (n = 21), Ogr1−/− (n = 10), Tdag8−/− (n = 14), and Ogr1−/− × Tdag8−/− (n = 10) littermate mice were exposed to DSS for 8 days, which resulted in pronounced colitis. Here, GPR68 is linked to inflammation.