Here, we revealed the degenerative changes in the astrocytic branching in the cerebellum within early AD onset (Figure 6a–e), accompanied by astrocytic death (Figure 6f,g), and the reduced number of the co-localized Lynx1 and α7-nAChR clusters in the vicinity of the astrocyte (Figure 6h,i). The gene discussed is LYNX1; the disease is Alzheimer disease.