Here, we detected down-regulated expression of the genes coding the SLURP-1, Lypd6b and Lynx1 proteins in the cerebellum of 2xTg-AD mice in comparison with non-transgenic (Tg−) mice (Figure 1b,c,e and Figure S1a,d,e). The gene discussed is LYPD6B; the disease is Alzheimer disease.