Surprisingly, the mRNA level of PSCA and Lypd6 was up-regulated in 2xTg-AD mice, while expression of GPI-anchored forms of the PSCA and Lypd6 proteins was fully absent in the cerebellum of 2xTg-AD mice in comparison with Tg− mice (Figure 1a,d). The gene discussed is LYPD6; the disease is Alzheimer disease.