On the other hand, with the ALCAR-based preventive protocol, a long-lasting anti-hyperalgesic efficacy has been achieved, and it was associated with a direct neuroprotective effect on enteric neurons, as attested by the protection from the neuronal damage caused by colitis and the further increase in PGP9.5 expression (neuronal marker) in the myenteric plexus. The gene discussed is UCHL1; the disease is colitis.