In a recent study, ALCAR was found to induce analgesia in mice modelling Fabry disease [46], an X-linked lysosomal storage disorder caused by deficient function of the alpha-galactosidase A (α-GalA) enzyme which leads to multisystemic clinical manifestations, among them neuropathic pain and gastrointestinal dysfunctions that appears in the early stage of the disease [47,48]. This evidence concerns the gene GLA and Fabry disease.