Figure 5D (gray circle) also reveals three independent relationships between different periodontitis-associated TFs. First, NR1H4, SOX11, and OTX2 regulate differentially expressed genes such as ABCB11, RP1, and DCLK1, respectively. Furthermore, FOXG1-TF exerts upper regulatory relationships by modulating the periodontitis target genes SERPINE1 and DMRT3. The gene discussed is SERPINE1; the disease is periodontitis.