SIX3 and periodontitis: To conduct a more in-depth analysis of our data, we selected only the nodes in the health and periodontitis conditions from the list of all the genes that appear in the modules shown in Figure 5B. This approach showed that the PAX6 transcription factor is a central regulator of the health-related network, composed of 10 genes (Figure 5C), and that SIX3 is both regulated by and a regulator of PAX6 (pink and black edges in Figure 5C).