In pathological conditions (Figure 5D), we detected 17 genes (BDNF, PITX3, EN1, PAX5, FCER2A, SPIC, MMP12, CD5L, SOX11, RP1, OTX2, DCLK1, NR1H4, ABCB11, SERPINE1, FOXG1, and DMRT3), including 6 exclusives to periodontitis (EN1, SPIC, SOX11, OTX2, NR1H4, and FOXG1). The gene discussed is SERPINE1; the disease is periodontitis.