Early adaptation of tumor cells to the drug was correlated with upregulation of JUN and downregulation of lymphoid enhancer binding factor 1 (LEF1) and sprouty RTK signaling antagonist 4 (SPRY4), and changes in the markers for epithelial-mesenchymal transition (EMT), as determined in cell cultures, xenografts in mice, and patient tumors [60]. This evidence concerns the gene LEF1 and neoplasm.