Another study reported nine somatic mutations in the amyloid beta precursor protein (APP), sortilin-related receptor 1 (SORL1), nicastrin (NCSTN) and microtubule affinity-regulating kinase 4 (MARK4) genes in patients with Alzheimer’s disease by next-generation sequencing (NGS) [22]. Here, NCSTN is linked to early-onset autosomal dominant Alzheimer disease.