To explore the mechanism of Rk1+Rg5 in the amelioration of T2DM, a bubble diagram was executed, as shown in Figure 1B. The analysis showed that these signaling pathways were closely associated with T2DM, and they included the insulin resistance, cAMP, PPAR, and p53 signaling pathways. This evidence concerns the gene TP53 and type 2 diabetes mellitus.