Next, we focused on differentially expressed genes using key driver genes’ (Insr, Irs1, Srebf2, PI3K, Akt, Glut4) analysis to further investigate the potential mechanism of Rk1+Rg5 in T2DM (Figure 6D); these genes were related to immune responses of the insulin signaling pathway, glucose transporters, and insulin resistance. Here, IRS1 is linked to type 2 diabetes mellitus.