SNAI1 and colorectal carcinoma: It has been demonstrated that SNAIL plays a crucial role in CRC, and elevated classical WNT signaling in CRC cells raises SNAIL levels, while SNAIL inhibits the E-cadherin-encoding gene CDH1 by binding to the E-box in the CDH1 promoter and recruiting the polycomb repressive complex, thereby regulating EMT and promoting local invasion [44,50,90,91].