Both cg11445109 and cg19469447 (annotated to CYP2E1 gene) were hypomethylated, with their methylation levels significantly lower in the MetS responder group compared to the MetS non-responder group both before surgery and six months after bariatric surgery, whilst cg25828445 (annotated to NIFKP3 gene) was shown to be hypermethylated, with significantly higher methylation levels in the MeS non-responder group compared to the MetS responder group, both before surgery and 6 months after bariatric surgery (Figure 1). The gene discussed is CYP2E1; the disease is metabolic syndrome.