Considering one of the possible mechanisms of oncogenic action of histone deacetylase 1, Shankar et al. [293] identified the HDAC1-mediated repression of Maspin, a tumor-suppressor gene that regulates cell invasion, angiogenesis, and apoptosis, processes important for both tumor growth and metastasis [294,295]. This evidence concerns the gene SERPINB5 and neoplasm.