AKT1 and neoplasm: Among the anti-tumor effects of quercetin is its ability to to induce cell cycle arrest in G2/M and G1 phases through the regulation of the PI3K/Akt [197] and MAPK signaling pathways [198], inhibit proliferation, and trigger cascades of apoptotic tumor cell death [199], as well as reverse resistance to the action of cytostatic agents [200].