PFKFB3 and neoplasm: For this reason, the study of the glycolytic function continues to expand, and, to date, it has been found that the intensity of glycolysis in tumor cells closely correlates with the activity of key glycolytic enzymes, hexokinase, 6-phosphofructo-2-kinase, and pyruvate kinase (Figure 5) [476], which catalyze the irreversible stages of this process; targeting them is thus a promising strategy for the repair of impaired tumor metabolism.