HDAC8 and cancer: By acting on both histone and non-histone substrates, overexpressed HDAC8 implements its oncogenic functions through the regulation of a number of signaling cascades in various types of malignant neoplasms, in particular, in hepatocellular carcinoma [355], gastric adenocarcinoma [356], acute lymphoblastic leukemia [357], squamous cell carcinoma of the oral cavity [358], neuroblastoma [359], etc. [360,361,362].