SOCS1 and myeloproliferative disorder: Thus, the study of the molecular mechanisms of the HDAC8-induced proliferation of tumor cells showed that, by reducing the expression of cytokine signaling suppressors 1 and 3 (SOCS1 and SOCS3), histone deacetylase 8 contributes to the constitutive activation of the Janus kinase signaling pathway 2/signal transducers and activators of transcription signaling (JAK2/STAT) [363], which play an important role in the oncogenesis of myeloproliferative neoplasms and leukemia [364].