As for cervical cancer, Liu et al. [297] found that the aberrant activity of HDAC1 in C-33A cells significantly increases the expression of octamer-binding embryonic transcription factor 4 (Oct4), a prognostic biomarker of various types of malignancies that plays a critical role in maintaining the pluripotency and self-renewal of embryonic stem cells [308,309,310,311]. The gene discussed is HDAC1; the disease is cervical carcinoma.