HOXA5 is downregulated in breast cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, lung cancer, osteosarcoma, and adrenocortical carcinoma but is overexpressed in oral squamous carcinoma, esophageal squamous carcinoma, glioma, and leukemia [23]. The gene discussed is HOXA5; the disease is osteosarcoma.