NFE2L2 and ovarian cancer: The data illustrated so far provide evidence that the overexpression of ZNF521 in HeyA8 and ES-2 human ovarian cancer cell lines induces a clear increase in the expression of NRF2 (only in the ES-2 cell line) and NOTCH component genes (Figure 1A and Figure 2A), as well as that of the corresponding proteins (Figure 1B and Figure 2B), both in 2D cultures and in non-anchorage-dependent cultures (Figure 3).