Furthermore, other cellular aspects, such as alterations in the extracellular matrix (ECM), the presence of extracellular vasculature, and the presence of extracellular vesicles released by cells in the tumor microenvironment (carrying oncogenic microRNAs and proteins involved in tumor progression such as CD147, CD276/B7-H3), play a key role in both tumor progression and the development of resistance to therapy [59]. The gene discussed is BSG; the disease is neoplasm.