SPARC and cancer: The increased levels of BMP4 (bone morphogenic protein), CEACAM1 (CEA cell adhesion molecule), COL5A2 (collagen type V alpha 2 chain), LAMA2 (laminin subunit alpha 2), NTN4 (netrin 4), PDGFB (platelet-derived GF subunit B), SERPINE1 (serpin family E member 1), SPOCK3 (osteonectin), and THBS1 (thrombospondin 1) indicated a wide variety of responses related to interactions with the extracellular matrix, which can represent an attempt of cancer cells to activate its invasive potential.