The increased levels of BMP4 (bone morphogenic protein), CEACAM1 (CEA cell adhesion molecule), COL5A2 (collagen type V alpha 2 chain), LAMA2 (laminin subunit alpha 2), NTN4 (netrin 4), PDGFB (platelet-derived GF subunit B), SERPINE1 (serpin family E member 1), SPOCK3 (osteonectin), and THBS1 (thrombospondin 1) indicated a wide variety of responses related to interactions with the extracellular matrix, which can represent an attempt of cancer cells to activate its invasive potential. This evidence concerns the gene LAMA2 and cancer.