However, with the lowering the expression of genes coding for proteins that take part in Ras signaling, including CRK-like proto-oncogene adaptor protein (CRKL) and Ras-like without CAAX 1 (RIT1), the GTPase regulating the p38 MAPK-dependent signaling cascade that responds to cellular stress, as well as MAPK7, could lead to the reduction of cancer cell proliferation and inhibition of its survival. This evidence concerns the gene CRKL and cancer.