MAPK7 and cancer: However, with the lowering the expression of genes coding for proteins that take part in Ras signaling, including CRK-like proto-oncogene adaptor protein (CRKL) and Ras-like without CAAX 1 (RIT1), the GTPase regulating the p38 MAPK-dependent signaling cascade that responds to cellular stress, as well as MAPK7, could lead to the reduction of cancer cell proliferation and inhibition of its survival.