Moreover, increased TIAM (T-lymphoma invasion and metastasis-inducing protein 1), a guanine nucleotide exchange factor (GEF) that regulates RAC1 signaling pathways affecting cell shape, migration, adhesion, growth, survival, actin cytoskeleton formation, endocytosis, and membrane trafficking, could contribute to activation of cancer cell migration and metastasis. Here, TIAM1 is linked to cancer.