Cellular energetics is also modulated by the NF-κΒ pathway, where the alternative NF-κΒ (RelB/p52 dimers) is activated by the IKK alpha dimer [79] to promote gluconeogenesis and oxidative metabolism instead of glycolysis, consistent with the downregulation of the IKK subtypes beta and gamma by some sarcoma subtypes. Here, RELB is linked to sarcoma.