ATF2 and breast cancer: However, comparing BC-treated Ztm male mice with Ztm control male mice, the downregulation was only significant for Atf2 (log2 = −22.39; q-value = 2.00 × 10−8), Atf2 XM_030246840 (log2 = −21.31; q-value = 2.93 × 10−6), and Atf2 XM_030246844 (log2 = −20.97).