In non-pathological conditions, renal endothelial cells do not express P-selectin; however, research has shown that P-selectin expression is increased in renal diseases, such as diabetic nephropathy and glomerular diseases (IgA nephropathy, minimal change disease, membranous nephropathy, mesangial proliferative glomerulonephritis, and LN) [182,183], particularly in diabetes when circulating P-selectin levels are significantly elevated, and even higher in diabetes with nephropathy [180,182]. This evidence concerns the gene SELP and kidney disorder.