In addition, through the analysis of the expression of HLA-related genes in the two groups, we found that there were significant differences in the expression of HLA-C, HLA-DMA, HLA-DMB, HA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DPB2, HLA-DRA, and HLA-DRB6 in the sepsis and control groups. The gene discussed is HLA-DPB1; the disease is Sepsis.