Exosomes isolated from human umbilical vein endothelial cells (HUVECs) were found to induce upregulated expression of VEGF in RCC, which correlated with the downregulation of hepatocyte cell adhesion molecule (HepCAM), a crucial tumor suppression gene that acts by inhibiting tumor angiogenesis [160]. The gene discussed is HEPACAM; the disease is neoplasm.