Utilizing a machine learning algorithm to develop an “EV-miRNA classifier” that could robustly stratify “CRPC-NE” from “CRPC-Adeno”, the authors identified thrombospondin 1 (TSP1) as a specific biomarker in the exosomes of their NEPC cellular models and proposed this as a potential novel EV biomarker for detecting NEPC in advanced castration-resistant prostate cancer patients [60]. Here, THBS1 is linked to prostate cancer.