In a study by Li et al. focusing on ccRCC, the authors found that EV mediates the transfer of ApoC1 from ccRCC cells to vascular endothelial cells, which is related to angiogenesis facilitation by activating STAT3 and augmenting the migratory and invasive capacities of endothelial cells [153]. Here, STAT3 is linked to nonpapillary renal cell carcinoma.