HDAC1 and malignant colon neoplasm: RBBP4 was identified as significantly overexpressed in human embryonal and glial brain cancers [18], BC [17], especially in TNBC tissues and cell lines [19], as well as in colon cancer cell lines, promoting malignant progression via increasing activity of the Wnt/β-catenin pathway, in correlation with a high expression of the histone deacetylase 1 (HDAC1) [20].