PRDM5/PFM2 is a zinc finger protein acting as an epigenetic modifier [113] known as a tumor suppressor; it is frequently silenced/downregulated/inactivated by methylation in multiple carcinoma lines, such as NPC, ESCC [114], GC [115], and HCC and ovarian, cervical, and breast cancers [113,116]. This evidence concerns the gene PRDM5 and esophageal squamous cell carcinoma.