Recently, based on proteomics–interactomics-based analysis and a lung cancer mouse model, DIABLO depletion was correlated with the inhibition of tumor cell growth and proliferation, decreased phospholipid levels, activated apoptosis, reversed EMT and altered TME, reduced expression of inflammation-related proteins such as NF-κB and TNF-α, and of the programmed death-ligand 1 (PD-L1), which is associated with immune system suppression [49]. This evidence concerns the gene TNF and lung cancer.