JTB and neoplasm: Interestingly, JTB overexpression has been correlated here with a plethora of significant upregulated and downregulated proteins that sustain JTB tumor suppressive functions, such as decreased cell growth, survival, motility, invasiveness and migration ability, cell proliferation, angiogenesis, colony formation, metabolism, and EMT in addition to an enhancement of apoptosis and other mechanisms of cancer cell death.