In the case of the LOEX-Protocol, the added first digestion step with thermolysin allows the detachment of the epidermis from the dermis due to its specific effect between the bullous pemphigoid, located at the lamina lucida of the epithelial side [25], and the laminin of the dermal compartment, disrupting the hemidesmosomes more easily but preserving the desmosomes between keratinocytes [26]. The gene discussed is LAMB2; the disease is bullous pemphigoid.