In contrast, adiponectin reduces tumor growth, HSC, and macrophage activation in orthotopic animal tumor models, downregulating angiogenesis through the inhibition of Rho kinase (ROCK)/IFN-inducible protein 10 (IP10)/vascular endothelial growth factor (VEGF) [77], while animal MASH models fed choline-deficient l-amino acid-defined (CDAA) diets exhibited hypoadiponectinemia which further aggravated fibrogenesis, inflammation and hepatocarcinogenesis [78]. Here, VEGFA is linked to adiponectin deficiency.