With respect to circulating inflammatory cells of the bloodstream, obesity is characterized by downregulation of CD8+ T cells and Tregs, with concomitant induction of M1 macrophages, CD4+ T cells, B cells, and NK cells [69,71], having an impact on the HCC’s tumor microenvironment (TME) [69,72,73,74,75]. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.