Elevated circulating levels of CHI3L1 have been observed in chronic inflammatory states such as RA, osteoarthritis (OA), inflammatory bowel disease (IBS), systemic lupus erythematosus (SLE), lichen planus, sarcoidosis, hepatic fibrosis, obesity, and other conditions [66,79,80]. The gene discussed is CHI3L1; the disease is Hepatic fibrosis.