ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The HMW form of adiponectin has anti-inflammatory properties and is linked to improved insulin sensitivity and glucose metabolism by promoting glucose uptake by fatty acid oxidation in muscle cells and the liver, while the LMW form has been linked to pro-inflammatory properties and is elevated in patients with metabolic disorders such as T2DM and obesity [49,50,51].