Intradermal injection of the mRNAs encoding melan-A, tyrosinase, gp100, MAGE-A1, MAGE-A3, and survivin decreases the frequency of forkhead Box P3+ (Foxp3+)/CD4+ regulatory T cells and Myeloid-derived suppressor cells (MDSCs) in metastatic melanoma patients [91]. Here, FOXP3 is linked to metastatic melanoma.