It is necessary to mention that a previous review reported findings similar to those of the present work: higher leptin concentrations, lower adiponectin, and conflicting results for resistin, TNF-α, and IL-6 in pregnant women with obesity compared to women with normal weight [42]; however, the present article proposes the pathophysiological mechanisms of dysregulated adipokines leading to obstetric complications. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.