Recent studies by Kabe et al. [72] have identified certain naturally occurring compounds (e.g., glycyrrhizin) that specifically bind to heme-dimerized PGRMC1 and interfere with the interaction of the PGRMC1 dimer with an EGF receptor, with functional consequences in terms of chemoresistance in colon cancer cells. This evidence concerns the gene PGRMC1 and malignant colon neoplasm.