PKD1 and autosomal dominant polycystic kidney disease: Other genes encoding components of the protein translocation apparatus of the endoplasmic reticulum membrane, such as SEC63, SEC61B, GANAB, PRKCSH, DNAJB11, ALG8, and ALG9, can diminish the functional dosage of PC1 by impairing its post-translational modification and trafficking to the cell membrane, modulating cystic disease severity in the setting of ADPKD [12].