Also, we found that A-alum-1 was able to modestly suppress the α-MSH-induced mRNA expression of MITF and tyrosinase in human melanoma SK-mel-28 cells (Figure 4E), similarly to that in B16F1 cells (Figure 4A,D), suggesting that A-alum-1 can inhibit melanogenesis through a transcriptional suppression-mediated mechanism. The gene discussed is TYR; the disease is melanoma.