ACSF3 and steatosis: Although it also has antioxidant and anti-inflammatory properties [116,117], PCA bound and upregulated the SIRT3 protein to prevent liver damage and steatosis in HFD-fed mice, likely by regulating the acetylation and degradation of Acyl-CoA synthetase family member 3 (ACSF3) and fatty acid metabolism [118].