In a diet-induced NAFLD and HCC mouse model, SREBP1 directly upregulated the expression of HDAC8, which worked with EZH2 concordantly through H4 deacetylation and H3K27 trimethylation to repress Wnt antagonists, thereby activating the Wnt pathway [87,88]. The gene discussed is EZH2; the disease is metabolic dysfunction-associated steatotic liver disease.