In addition, the herbal prescription Yang-Gan-Wan (YGW) and its active ingredients, rosmarinic acid (RA) and baicalin (BC), showed the potential to treat liver fibrosis by de-repressing Pparγ in an epigenetic-dependent way, which suppressed the expression of EZH2 and reduced H3K27 di-methylation [55]. This evidence concerns the gene EZH2 and Hepatic fibrosis.