Multiple proinflammatory/immune recruitment (IL-1β, IL-6, IL-8, TNFα, IFNα, MIP-1β, CXCL12) and immune suppressive cytokines (IL-10) were found to be induced by tumor line-derived sEVs but not those derived from normal pancreatic cell lines (Supplementary Figure S4B, Supplementary Table S1). This evidence concerns the gene CXCL12 and neoplasm.