WEE1 and acute lymphoblastic leukemia: However, since WEE1 downregulation at least contributed partly to the therapeutic effect of bortezomib in ALL, the WEE1 inhibition in ALL cells with low-level expression of WEE1 may greatly diminish the effect of WEE1 downregulation by bortezomib and, hence, jeopardize the therapeutic effect of bortezomib.