OXT and amyotrophic lateral sclerosis: The anterior and superior tuberal subregions of the hypothalamus containing the paraventricular nucleus (housing oxytocin-producing neurons) display considerable volume loss in ALS and ALS-FTD, while the inferior tuberal subregions with the paraventricular nucleus (containing neuroendocrine neurons) were relatively preserved, supporting discrete neuropeptide expression abnormalities that may potentially underlie the pathogenesis of certain cognitive and behavioral symptoms in this disease spectrum [91].