TDP-43 burden in the limbic system (amygdala, dentate nucleus, CA1 sector of the hippocampus, subiculum, and entorhinal cortex) was greater in older than in younger ALS patients, indicating that the amygdala and hippocampus are vulnerable to TDP-43 pathology in older ALS patients [170]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.