The most consistent ALS and ALS-FTLD pathology is a disturbance in transactive response DNA-binding protein 43 kDA (TDP-43) metabolism, observed in up to 97% of all cases [15,16], with phosphorylated TDP-43 pathology causing a disruption of synaptic structures [17,18]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.