-HERV-K (HML-2) expression has been implicated in colon cancer progression. Studies have shown that increased HERV-K (HML-2) expression correlates with disease progression, lymph node metastasis, and reduced overall survival in patients with colon cancer.-Targeting HERV-K (HML-2) proteins, such as the env protein, may hold promise as a therapeutic strategy in colon cancer [68]. Here, ERVW-1 is linked to metastatic malignant neoplasm in the lymph nodes.