The present study warrants future studies of the effects of the AIN93M diet on these serotonergic autoreceptors and heteroreceptors since 4-weeks of CUMS could not induce behavioural despair (depression-like behaviour) in mice on the AIN93M diet but did result in an anxiety-like phenotype, suggesting improved stress coping in these mice due to the increased TPH2 levels and lack of depressive-like behaviour in the TST. Here, TPH2 is linked to major depressive disorder.