Data reported by Yang et al. [187] have shown how a combined action of different polyphenols influences gut microbiota diversity and structure during mice colitis-related carcinogenesis (CRC) and how these changes, in turn, influence the success of treatment having a regulatory effect on 17 signaling pathways involved in related genes, including several biomarkers associated with CRC, such as COX-2, EMR1, PCNA, and caspase-3, which were strongly changed by polyphenol treatment. This evidence concerns the gene ADGRE1 and colorectal carcinoma.