Fisetin attenuates phosphorylation of Akt and p38, but not of ERK and JNK, in dextran sulfate sodium (DSS)-induced colitis in mice [107], and proanthocyanidins act on JNK, ERK, and PI3K/Akt phosphorylation in a rat hepatic stellate cell line [108]. The gene discussed is MAPK8; the disease is colitis.