Still on Hemophilia-related pathologies a very interesting study was conducted by Balestra et al. [54] that challenged the efficacy of a U1 snRNA-mediated strategy for splicing mutations occurring at the 3′ss, 5′ss or within exon 5 of the F8 (FVIII) gene (see Table 1) and associated with different severity degrees of Coagulation factor VIII (FVIII) deficiency (Hemophilia A). The gene discussed is F8; the disease is hemophilia.