Vice versa, ubiquitination of NRF2 can be removed by de-ubiquitinating enzymes (DUBs) because ubiquitination is a dynamic and reversible process, and this process in non-small cell lung cancer (NSCLC) is mediated by ubiquitin-specific processing protease 11 (USP11) [63]. This evidence concerns the gene USP11 and non-small cell lung carcinoma.