This intermediate phenotype stands in contrast to the TSD (Hexa−/−) and SD (Hexb−/−) murine models, with TSD mice exhibiting no behavioral or biochemical impairments and a normal lifespan, while SD mice experience cytotoxic GM2 accumulation, motor impairment, and early death at 14–16 weeks of age [45]. Here, HEXB is linked to Tay-Sachs disease.