Thus, the AMPK-ATGL pathway does not contribute to the inhibition of hyperlipidemia in mice, suggesting that the activation of the AMPK-ACC1 and AMPK-ACC2 pathways is a necessary condition for the mouse liver to enhance the absorption of exogenous fatty acids, which are then converted into TG and transferred outside the liver. Here, PNPLA2 is linked to hyperlipidemia.