Those hepatic lesions were stained with CK-19 (Figure 2B), and a part of the atypical biliary ducts showed a high nuclear/cytoplasm ratio and finely granular chromatin in the AOM-treated obese mice (Figure 2A and Figure S1B); this indicated that the hepatic lesions were cancerous and that they could be considered to be intrahepatic cholangiocarcinoma. This evidence concerns the gene KRT19 and infectious otitis media.