Debris of degenerating neurons might be an activator for microglia, and neuromelanin has been shown to induce neuroinflammation in rat substantia nigra [223]; however, the finding that T cells from PD patients recognize specific α-synuclein epitopes [210] opens the interesting perspective of a trigger for neuroinflammation in PD outside the nervous system. Here, SNCA is linked to Parkinson disease.