To test if Gpc1−/− lungs showed different susceptibility to a sepsis model of acute lung injury (ALI), we assessed their susceptibility to develop pulmonary edema, a known outcome of acute lung injury and ARDS, using sepsis model, in which mice were injected with LPS 10 mg/Kg, intraperitoneally. The gene discussed is GPC1; the disease is acute respiratory distress syndrome.