ADAM17 and Miyoshi myopathy: Figure 1A demonstrates varying levels of JAG ligand expression within the examined MM cell lines. Notably, JAG1 exhibited higher expression levels compared to JAG2, with all cell lines expressing at least one of these ligands. Furthermore, we detected the presence of the JAG1 intracellular domain (JAG1-ICD), released subsequent to Notch engagement by ADAM-17 and γ-Secretase [29], across all cell lines.