TRPA1 and hydrops fetalis: Moreover, it was reported that OleA modulates several receptors to exert its beneficial health effects; for example, it acts on human epidermal growth factor receptor 2 (HER2) in breast cancer [66] or activates transient receptor ankyrin potential 1 (TRPA1) and vanilloid receptor 1 (TRPV1) to reduce visceral fat content in obese rats induced by a HF diet [67].