In detail, Elizabethkingia miricola crossing the blood–brain barrier (BBB) into the brain induce the pattern recognition receptors (PRRs) to interact with pathogenic lipopolysaccharides (LPS) and peptidoglycans (PGN), inciting the further activation of inflammasomes and NFκBs via the “NOD-like receptor signaling pathway” and the “Toll-like receptor signaling pathway”, thus promoting the transcription and expression of IL-8, IL-1β, and CXCL10 and leading to bacterial meningitis, but further research is needed to confirm these speculations. This evidence concerns the gene CXCL8 and bacterial meningitis.