In mouse models of chronic pancreatitis [32], genetic perturbation of the circadian master clock circuits (BMAL1/CLOCK, RORA/REVERBA) resulted in TGFβ-IL11/IL11RA-dependent progressive pancreatic fibrosis and exocrine dysfunction due to the fibrogenic properties of pancreatic stellate cells and secretory activity of acinar cells. The gene discussed is CLOCK; the disease is fibrosis.