In melanoma, as in other cancers, one of the main mechanisms underlying cancer cell dissemination is the epithelial-to-mesenchymal transition (EMT), a multi-step process involving several molecular and cellular modifications, such as the downregulation of gene coding for epithelial proteins (i.e., E-cadherin/CDH1 and occludin/OCLN, etc.)and the upregulation of gene coding for mesenchymal markers (i.e., N-cadherin/CDH2, fibronectin/hFN1, and vimentin/VIM, etc.)[17,18]. The gene discussed is CDH1; the disease is melanoma.