In addition, the positive ratio of RF-IgA was higher in patients with RA-ILD than that in patients with RA without ILD, whereas the positive ratios of RF-IgG, RF-IgM, anti-AKA antibodies, anti-APF antibodies, and ACPA were not significantly different between the two groups [96]. The gene discussed is CD40LG; the disease is rheumatoid arthritis.