Gene set enrichment analysis proteins affecting these gene sets in RA-ILD included several proteins involved in lung fibrosis: cytokines (CCL18 and IL-17), chemokines (CXCL12 and CCL5), FGF family members (FGF4 and FGF7), and S-type lectin galectin-3 (LGALS3) [158]. This evidence concerns the gene CXCL12 and interstitial lung disease.