It was demonstrated that the expressions of CX3CL1 and CX3CR1 were up-regulated in the lung tissues of BLM-IP mouse, and the inhibition of CX3CL1 by treating anti-CX3CL1 mAb decreased the population of M1 macrophages and increased surface CD3 expressions on T cells of BALF [160]. The gene discussed is CX3CL1; the disease is incontinentia pigmenti.